With an increasing number of global assessments, studies, and reports on the effectiveness of Nature-based Solutions (NbS) and Ecosystem-based Adaptation (EbA), this brief provides state-of-the-art summary and analysis of the latest science–policy interface assessments and relevant reports related to NbS and EbA. It outlines the evidence base for the ability of NbS and EbA to deliver multiple benefits and transformative change to solve societal and environmental challenges and provides forward-looking recommendations on scaling up the implementation and support of NbS and EbA. This brief is targeted toward policy-makers, climate change and biodiversity practitioners as well as UNFCCC and CBD negotiators.